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Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2018
-
Abstract
- Marine plants and animals have omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is required for biological processes, but humans are unable to synthesize them and must be obtained from dietary sources. EPA has been used as an antitumor agent but the molecular mechanisms for the regulation of tumor microenvironment immunity by EPA are still unknown. The indoleamine 2,3-dioxygenase 1 (IDO) catalyzes conversion of tryptophan to kynurenine to induce immune evasion in tumor microenvironment. In this study, EPA inhibited the expression of IDO via downregulation of protein kinase B (Akt)/mammalian targets of rapamycin (mTOR) signaling pathway in tumor cells. Meanwhile, a significant decrease in kynurenine levels and increase in T cell survival were observed after tumor cells treated with EPA. The results demonstrated that EPA can activate host antitumor immunity by inhibiting tumor IDO expression. Therefore, our finding suggests that EPA can be enormous potential for cancer immunotherapy.
- Subjects :
- 0301 basic medicine
Eicosapentaenoic acid
indoleamine 2,3-dioxygenase
T-Lymphocytes
Down-Regulation
complex mixtures
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Tumor Cells, Cultured
Animals
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
tumor microenvironment
Indoleamine 2,3-dioxygenase
Protein kinase B
PI3K/AKT/mTOR pathway
health care economics and organizations
immune evasion
Tumor microenvironment
Chemistry
General Medicine
social sciences
030104 developmental biology
Docosahexaenoic acid
Cancer research
030211 gastroenterology & hepatology
lipids (amino acids, peptides, and proteins)
immunotherapy
Proto-Oncogene Proteins c-akt
Kynurenine
Signal Transduction
Research Paper
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 15
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International journal of medical sciences
- Accession number :
- edsair.doi.dedup.....787cb8d040e82df0ed6de74c4f7021f7