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Factors predicting the outcome of stevens–Johnson syndrome and toxic epidermal necrolysis: A 5-year retrospective study
- Source :
- Indian Dermatology Online Journal, Indian Dermatology Online Journal, Vol 12, Iss 2, Pp 258-265 (2021)
- Publication Year :
- 2021
- Publisher :
- Medknow, 2021.
-
Abstract
- Background: Clinicodemographic and laboratory parameters predicting the outcome of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) may vary among populations owing to genotypic and environmental variations. There is a scarcity of studies evaluating these parameters in Indian population. Aims: To analyze clinicodemographic and laboratory parameters predicting disease outcome in patients of SJS/TEN. Materials and Methods: Clinical records of patients admitted with a diagnosis of SJS/TEN from January 2014 to December 2018 were reviewed retrospectively with respect to data pertaining to clinicodemographic details, laboratory parameters, and disease outcome. Results: Of 51 patients included in the study, 24 (47.06%) were females. Anticonvulsants [phenytoin (19.6%), carbamazepine (13.7%), others (5.88%)] were the most commonly implicated drugs followed by NSAIDs (19.6%). The overall mortality was 21.6% [SJS (0%), SJS-TEN overlap (18.8%), and TEN (28.6%)]. The mean detached body surface area (BSA) (35.4% ± 10.4% vs. 25.7% ± 11.8%; P = 0.02) was significantly higher among patients with mortality. Blood urea nitrogen, serum HCO3− levels, and random blood sugar were significantly associated with mortality. Presence of sepsis during the disease course was associated with higher mortality (9/12 vs. 2/39; P = 0.001). Other components of SCORTEN like age and heart rate were not significantly associated with poor outcome in our study. None of our patients had associated malignancy. Conclusion: A higher detached BSA, presence of sepsis, higher blood urea nitrogen and random blood sugar, and lower serum HCO3− levels were associated with mortality. Refinement of scoring systems predicting the outcome of SJS-TEN is needed for better disease prognostication.
- Subjects :
- Phenytoin
medicine.medical_specialty
SCORTEN
Malignancy
Sepsis
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
toxic epidermal necrolysis
Internal medicine
lcsh:Dermatology
medicine
Blood urea nitrogen
Body surface area
business.industry
Retrospective cohort study
Steven–Johnson syndrome
Carbamazepine
lcsh:RL1-803
medicine.disease
Toxic epidermal necrolysis
stomatognathic diseases
030220 oncology & carcinogenesis
Original Article
business
medicine.drug
Subjects
Details
- ISSN :
- 22295178
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Indian Dermatology Online Journal
- Accession number :
- edsair.doi.dedup.....787c40022122903f6ab143b04837e861