Back to Search
Start Over
Two new lignans from twigs of Aglaia odorata
- Source :
- Journal of Asian Natural Products Research. 18:147-152
- Publication Year :
- 2015
- Publisher :
- Informa UK Limited, 2015.
-
Abstract
- HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.
- Subjects :
- Pharmaceutical Science
01 natural sciences
Lignans
Analytical Chemistry
HeLa
Stomach Neoplasms
Drug Discovery
Botany
medicine
Humans
Cytotoxicity
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
Meliaceae
Molecular Structure
Plant Stems
biology
010405 organic chemistry
Chemistry
Aglaia odorata
Organic Chemistry
Cancer
General Medicine
biology.organism_classification
medicine.disease
Antineoplastic Agents, Phytogenic
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
3'-methoxy-N-demethylrocaglamide
Molecular Medicine
Drug Screening Assays, Antitumor
Aglaia
Human cancer
Drugs, Chinese Herbal
HeLa Cells
Subjects
Details
- ISSN :
- 14772213 and 10286020
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Asian Natural Products Research
- Accession number :
- edsair.doi.dedup.....7877e09ffeca021157646243763d6e2a