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Technology development of hyperthermic pressurized intraperitoneal aerosol chemotherapy (hPIPAC)
- Source :
- Surgical Endoscopy
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Optimized drug delivery systems are needed for intraperitoneal chemotherapy. The aim of this study was to develop a technology for applying pressurized intraperitoneal aerosol chemotherapy (PIPAC) under hyperthermic conditions (hPIPAC). Methods This is an ex-vivo study in an inverted bovine urinary bladder (IBUB). Hyperthermia was established using a modified industry-standard device (Humigard). Two entry and one exit ports were placed. Warm-humid CO2 was insufflated in the IBUB placed in a normothermic bath to simulate body thermal inertia. The temperature of the aerosol, tissue, and water bath was measured in real-time. Results Therapeutic hyperthermia (target tissue temperature 41–43 °C) could be established and maintained over 30 min. In the first phase (insufflation phase), tissue hyperthermia was created by insufflating continuously warm-humid CO2. In the second phase (aerosolization phase), chemotherapeutic drugs were heated up and aerosolized into the IBUB. In a third phase (application phase), hyperthermia was maintained within the therapeutic range using an endoscopic infrared heating device. In a fourth phase, the toxic aerosol was discarded using a closed aerosol waste system (CAWS). Discussion We introduce a simple and effective technology for hPIPAC. hPIPAC is feasible in an ex-vivo model by using a combination of industry-standard medical devices after modification. Potential pharmacological and biological advantages of hPIPAC over PIPAC should now be evaluated.
- Subjects :
- Dynamic Manuscript
Hyperthermia
medicine.medical_treatment
Technology development
Intraperitoneal chemotherapy
03 medical and health sciences
0302 clinical medicine
Therapeutic Hyperthermia
medicine
Animals
Humans
Industrial Development
Aerosol
Aerosolization
Aerosols
Chemotherapy
business.industry
Hyperthermia, Induced
medicine.disease
030220 oncology & carcinogenesis
Drug delivery
Medical devices
Cattle
Laparoscopy
030211 gastroenterology & hepatology
Surgery
business
Biomedical engineering
Subjects
Details
- ISSN :
- 14322218 and 09302794
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Surgical Endoscopy
- Accession number :
- edsair.doi.dedup.....787709cf23f11b47c6099601f07532b0