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Factors influencing platelet reactivity in patients undergoing coronary artery bypass surgery
- Source :
- Coronary Artery Disease. 27:185-190
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- OBJECTIVE Because coronary artery bypass graft (CABG) surgery is associated with a high turnover of platelets, assessment of platelet function should enable assessment of the effect of young (RNA-containing) platelets on platelet reactivity. This study was designed to assess platelet reactivity 1 day after CABG in patients treated previously with clopidogrel or ticagrelor. METHODS Patients (n=18) with acute coronary syndrome who required urgent CABG and had been treated for up to 2 days before surgery with aspirin plus clopidogrel (n=13) or aspirin plus ticagrelor (n=5) were enrolled. Care was not altered by participation, which entailed review of medical records and taking one sample of blood 1 day after surgery. The percentage of RNA-containing platelets was quantified using thiazole orange, and platelet function was assessed by flow cytometry. RESULTS Young platelets constituted, on average, 24% of platelets (range 4-54%) and were more likely to be activated in the absence or presence of an agonist (P
- Subjects :
- Blood Platelets
Male
Ticagrelor
Acute coronary syndrome
medicine.medical_specialty
Adenosine
Ticlopidine
Time Factors
Platelet Aggregation
Platelet Function Tests
030204 cardiovascular system & hematology
03 medical and health sciences
Coronary artery bypass surgery
0302 clinical medicine
P2Y12
Predictive Value of Tests
Internal medicine
Humans
Medicine
Platelet
cardiovascular diseases
030212 general & internal medicine
Acute Coronary Syndrome
Coronary Artery Bypass
Aged
Aspirin
business.industry
General Medicine
Middle Aged
Flow Cytometry
medicine.disease
Clopidogrel
Treatment Outcome
medicine.anatomical_structure
Purinergic P2Y Receptor Antagonists
Cardiology
Drug Therapy, Combination
Female
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
medicine.drug
Artery
Subjects
Details
- ISSN :
- 09546928
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Coronary Artery Disease
- Accession number :
- edsair.doi.dedup.....786875b2961a78dc6e121215c5e35401