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Effect of hibernation, thyroid hormones and dexamethasone on cytosolic and mitochondrial glycerol-3-phosphate dehydrogenase from jerboa (Jaculus orientalis)
- Source :
- Comparative Biochemistry and Physiology-Part B: Biochemistry and Molecular Biology, Comparative Biochemistry and Physiology-Part B: Biochemistry and Molecular Biology, Elsevier, 2000, pp.439-49
- Publication Year :
- 2000
- Publisher :
- HAL CCSD, 2000.
-
Abstract
- International audience; Tissue distribution of the cytosolic and mitochondrial glycerol-3-phosphate dehydrogenase (cGPDH and mGPDH) activities in jerboa (Jaculus orientalis), a hibernator, shows the highest level of enzyme activity in skeletal muscle and brown adipose tissue, respectively. The effect of hibernation on cGPDH indicates an increase of activity in all tissues examined. In contrast, hibernation decreases mGPDH activity in all tissues, except skeletal muscle. The effect of thyroid hormones on GPDH activity was tissue specific: in kidneys, cGPDH activity doubled in euthermic jerboas treated with T4. In contrast, 6-n-propyl-2-thiouracil treatment provokes an increase of enzyme activity in brown adipose tissue, liver and brain. T4 treatment leads to a 2.7-fold increase in liver mGPDH activity. 6-n-propyl-2-thiouracil treatment decreases mGPDH activity in the skeletal muscle whereas the opposite effect was observed in brain. Dexamethasone stimulates cGPDH in all tissues examined, except skeletal muscle and kidneys. In the case of mGPDH activity, this increase was observed only for brown adipose tissue and brain. Our results suggest that hibernation, thyroid hormones and dexamethasone probably play a role in the regulation of cGPDH and mGPDH activities in jerboa. Our findings confirm that these enzymes are involved in metabolic adaptation to thermal stress in Jaculus orientalis.
- Subjects :
- Hibernation
Male
Physiology
Adipose tissue
MESH: Rodentia
Mitochondrion
Kidney
Biochemistry
Dexamethasone
Cytosol
Adipose Tissue, Brown
MESH: Cytosol
Brown adipose tissue
MESH: Animals
MESH: Muscle, Skeletal
MESH: Propylthiouracil
biology
Brain
MESH: Glycerolphosphate Dehydrogenase
Mitochondria
medicine.anatomical_structure
Liver
MESH: Dexamethasone
MESH: Hibernation
medicine.medical_specialty
Thyroid Hormones
MESH: Mitochondria
Glycerolphosphate Dehydrogenase
Rodentia
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Adipose Tissue, Brown
MESH: Brain
[SDV.CAN] Life Sciences [q-bio]/Cancer
MESH: Thyroid Hormones
Internal medicine
medicine
Animals
Muscle, Skeletal
Molecular Biology
Jaculus orientalis
Skeletal muscle
MESH: Kidney
biology.organism_classification
Enzyme assay
MESH: Male
Endocrinology
Glycerol-3-phosphate dehydrogenase
Propylthiouracil
biology.protein
MESH: Liver
Subjects
Details
- Language :
- English
- ISSN :
- 10964959
- Database :
- OpenAIRE
- Journal :
- Comparative Biochemistry and Physiology-Part B: Biochemistry and Molecular Biology, Comparative Biochemistry and Physiology-Part B: Biochemistry and Molecular Biology, Elsevier, 2000, pp.439-49
- Accession number :
- edsair.doi.dedup.....78676c61a8730820aed1b208ee924b3a