Back to Search
Start Over
Effects of vitamin E deficiency and non-biological antioxidant (DPPD) on the function of the pituitary-gonadal axis of the rat
- Source :
- Journal of Nutritional Science and Vitaminology. 32:41-54
- Publication Year :
- 1986
- Publisher :
- Center for Academic Publications Japan, 1986.
-
Abstract
- The effects of vitamin E deficiency on pituitary-gonadal function in rats and the preventive effects of N,N'-diphenyl-p-phenylene diamine (DPPD) administration were examined by measuring levels of pituitary and plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH), serum and testicular levels of testosterone, and affinity and receptor sites of FSH and LH in the testis by radioimmunoassay, at 180 days after feeding of a vitamin E-deficient diet and DPPD-administered diet. Light and electron microscopic examinations were also performed on the pituitary gland and testis. In the vitamin E-deficient rats, serum and liver alpha-tocopherol concentrations decreased significantly and erythrocyte hemolytic rate and serum and tissue malondialdehyde levels increased significantly. However, the increase of hemolytic rate and malondialdehyde concentration in the vitamin E-deficient rats was somewhat lessened by the administration of DPPD. In the vitamin E-deficient rats, the gonadotropic cells in the pituitary gland manifested accelerated secretory function indicated by enlargement of cells, development of Golgi apparatus and accumulation of secretory granules, while FSH and LH concentrations in the pituitary and serum were not affected by vitamin E deficiency. However, the testosterone concentrations in the plasma and testis were significantly lower in the vitamin E-deficient rats. The decrease of testosterone in plasma and tissue was prevented by the administration of DPPD, while the degeneration of seminiferous tubules was not completely restored by DPPD. It is concluded that DPPD can compensate to some degree for the lack of antioxidative activity due to vitamin E deficiency.
- Subjects :
- Male
Vitamin
medicine.medical_specialty
Pituitary gland
Antioxidant
medicine.medical_treatment
Medicine (miscellaneous)
Receptors, Cell Surface
Phenylenediamines
Biology
Hemolysis
Antioxidants
chemistry.chemical_compound
Malondialdehyde
Internal medicine
Testis
medicine
Animals
Vitamin E
Testosterone
Vitamin E Deficiency
Nutrition and Dietetics
Body Weight
Rats, Inbred Strains
Pituitary gonadal axis
Organ Size
Luteinizing Hormone
Receptors, LH
Rats
Endocrinology
medicine.anatomical_structure
Liver
chemistry
Pituitary Gland
Receptors, FSH
Vitamin E deficiency
Follicle Stimulating Hormone
Luteinizing hormone
Hormone
Subjects
Details
- ISSN :
- 18817742 and 03014800
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Nutritional Science and Vitaminology
- Accession number :
- edsair.doi.dedup.....78668a0237cf9cf21c2b74602a6a3c1b