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Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer’s disease continuum
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.
- Subjects :
- Male
Disease
Article
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Metastability
Neural Pathways
Humans
Cognitive Dysfunction
0501 psychology and cognitive sciences
Effects of sleep deprivation on cognitive performance
Association (psychology)
Aged
Brain Mapping
Multidisciplinary
Computational neuroscience
Quantitative Biology::Neurons and Cognition
Mechanism (biology)
business.industry
Putamen
05 social sciences
Brain
Cognition
Middle Aged
Magnetic Resonance Imaging
Cross-Sectional Studies
Female
Artificial intelligence
business
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....78617bb7ccf07ebeeb5e671122272c69