Back to Search
Start Over
Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
- Source :
- Circulation. 112(14)
- Publication Year :
- 2005
-
Abstract
- Background— The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue. To explore this association, we tested 2 hypotheses: (1) that N-terminal (NT)-proBNP, which is not believed to bind NPR-C, would not be associated with BMI and (2) that lower BNP would be more closely associated with fat mass than with lean mass. Methods and Results— Measurements of BNP, NT-proBNP, and body composition by direct dual energy x-ray absorptiometry (DEXA) were performed in 2707 subjects from the Dallas Heart Study. The associations between obesity and low BNP (P Conclusions— In a large, population-based cohort, we confirm the previously described association between higher BMI and lower BNP and demonstrate a similar inverse association between BMI and NT-proBNP. Interestingly, both BNP and NT-proBNP are more closely associated with lean mass than with fat mass. These findings do not support the hypothesis that the lower BNP levels seen in obesity are driven by enhanced BNP clearance mediated via NPR-C.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Adipose tissue
Logistic regression
Absorptiometry, Photon
Physiology (medical)
Internal medicine
Natriuretic Peptide, Brain
Natriuretic peptide
Medicine
Humans
cardiovascular diseases
Obesity
Aged
business.industry
Body Weight
Middle Aged
medicine.disease
Texas
Peptide Fragments
Endocrinology
Quartile
Lean body mass
Body Composition
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Hormone
Subjects
Details
- ISSN :
- 15244539
- Volume :
- 112
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....783db01a9ba6b3123d96b5c89e8aebc6