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Cost analysis of vaccination in tick-mouse transmission of Lyme disease
- Source :
- Journal of Theoretical Biology. 494:110245
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Lyme disease is one of the most prevalent and fastest growing vector-borne bacterial illnesses in the United States, with over 25,000 new confirmed cases every year. Humans contract the bacterium Borrelia burgdorferi through the bite of the tick Ixodes scapularis. The tick can receive the bacterium from a variety of small mammal and bird species, but the white-footed mouse Peromyscus leucopus is the primary reservoir in the northeastern United States, especially near human settlement. The tick's life cycle and behavior depend greatly on the season, with different stages of tick biting at different times. Reducing the infection in the tick-mouse cycle may greatly lower human Lyme incidence in some areas. However, research on the effects of various mouse-targeted interventions is limited. One particularly promising method involves administering vaccine pellets to white-footed mice through special bait boxes. In this study, we develop and analyze a mathematical model consisting of a system of nonlinear difference equations to understand the complex transmission dynamics and vector demographics in both tick and mice populations. We evaluate to what extent vaccination of white-footed mice can affect Lyme incidence in I. scapularis, and under which conditions this method saves money in preventing Lyme disease. We find that, in areas with high human risk, vaccination can eliminate mouse-tick transmission of B. burgdorferi while saving money.
- Subjects :
- 0301 basic medicine
Statistics and Probability
Peromyscus
Zoology
Tick
General Biochemistry, Genetics and Molecular Biology
Mice
03 medical and health sciences
0302 clinical medicine
Lyme disease
parasitic diseases
medicine
Animals
Borrelia burgdorferi
Lyme Disease
Ixodes
General Immunology and Microbiology
biology
Transmission (medicine)
Applied Mathematics
Vaccination
General Medicine
Models, Theoretical
bacterial infections and mycoses
biology.organism_classification
medicine.disease
LYME
030104 developmental biology
Ixodes scapularis
Modeling and Simulation
Costs and Cost Analysis
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00225193
- Volume :
- 494
- Database :
- OpenAIRE
- Journal :
- Journal of Theoretical Biology
- Accession number :
- edsair.doi.dedup.....783703049ba0dbeed075bdc0d1bd9405