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Prognostic Factors in Acute Promyelocytic Leukemia: A Retrospective Study of 67 Cases
- Source :
- Leukemia & Lymphoma. 4:249-256
- Publication Year :
- 1991
- Publisher :
- Informa UK Limited, 1991.
-
Abstract
- In a cohort of 67 adult patients with newly diagnosed untreated acute promyelocytic leukemia (APL), the initial clinical and biological parameters were submitted to multivariate analysis for potential prognostic significance. Median age of the patients was 40 years and the hematologic characteristics of the patients were those regularly seen. Complete remission (CR) was achieved in 43 cases (64%). Fourteen patients died within 4 weeks of diagnosis, due to severe hemorrhage. Factors predictive of hemorrhagic death in the multivariate analysis were hyperuricemia (p = 0.001), splenomegaly (p = 0.009), anemia (p = 0.02), high serum levels of LDH (p = 0.02), increased prothrombin time (p = 0.04), and hypercreatininemia (p = 0.05). Pretreatment patient characteristics for poor prognosis and achieving CR were hyperuricemia (p = 0.0002), splenomegaly (p = 0.01), anemia (p = 0.02), and lymphadenopathy (p = 0.04). The median disease-free survival (DFS) was 15.6 months. Poor prognostic factors for DFS were hyperuricemia (p = 0.007), and splenomegaly (p = 0.03). Maintenance chemotherapy had no statistically significant impact on CR duration. Median survival duration was 10 months. Poor prognostic factors for survival were hyperuricemia (p = 0.0005), and elevated serum LDH levels (p = 0.01).
- Subjects :
- Acute promyelocytic leukemia
Cancer Research
medicine.medical_specialty
Poor prognosis
Multivariate analysis
Anemia
business.industry
Patient characteristics
Retrospective cohort study
Hematology
medicine.disease
Gastroenterology
Oncology
Internal medicine
Immunology
Cohort
medicine
Hyperuricemia
business
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....78355445ec203f6818b908644446d0a4