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Disseminated cutaneous immunoglobulin M macroglobulinosis associated with cryoglobulinemia and minimal residual disease of Waldenström macroglobulinemia
- Source :
- JAAD Case Reports
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- The dermatologic manifestations of Waldenstrom macroglobulinemia (WM) are typically categorized as disease specific or non–disease specific.1 Non–disease-specific findings are related to hyperviscosity or cryoglobulinemia, including mucosal bleeding, purpura, livedo reticularis, and Raynaud phenomenon. Two rare types of specific skin findings have been identified: cutaneous infiltrates of mature B-cell neoplasms, specifically heavy-chain or malignant immunoproliferative diseases, and deposits of monoclonal immunoglobulin (Ig) M, referred to as cutaneous macroglobulinosis (CM). Although classically described in patients with WM, cutaneous deposition could develop in any condition associated with IgM paraproteinemia. First documented in 1978 by Tichenor et al,2 CM is remarkable for its association with underlying plasma cell dyscrasias and its ability to mimic other depositional disorders. Here, we report a patient initially diagnosed with lymphoplasmacytic lymphoma (LPL) whose subsequent development of neuropathy and hyperviscosity syndrome due to elevated serum IgM led to a diagnosis of WM. The patient then developed a disseminated cutaneous presentation of CM, with minimal residual WM disease and cryoglobulinemia.
- Subjects :
- R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone
Paraproteinemia
Pathology
medicine.medical_specialty
IgM
Case Report
Dermatology
cryoglobulinemia
Lymphoplasmacytic Lymphoma
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
cutaneous macroglobulinosis
Hyperviscosity syndrome
medicine
Livedo reticularis
BMB, bone marrow biopsy
Waldenström macroglobulinemia
WM, Waldenström macroglobulinemia
biology
business.industry
Waldenstrom macroglobulinemia
medicine.disease
LPL, lymphoplasmacytic lymphoma
Minimal residual disease
Cryoglobulinemia
Ig, immunoglobulin
CM, cutaneous macroglobulinosis
Immunoglobulin M
030220 oncology & carcinogenesis
biology.protein
medicine.symptom
PAS, periodic acid Schiff
business
Subjects
Details
- Language :
- English
- ISSN :
- 23525126
- Volume :
- 5
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- JAAD Case Reports
- Accession number :
- edsair.doi.dedup.....781bee9c9496fae84d453c5ea1258e69