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Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents
- Source :
- ACS combinatorial science. 19(3)
- Publication Year :
- 2017
-
Abstract
- The potent kinesin spindle protein inhibitor CPUYJ039 and a set of analogues were prepared by a target-oriented approach based on a Ugi reaction that uses 2-nitrophenyl isocyanides as key building blocks. The herein documented strategy provides straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploring the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
- Subjects :
- CPUYJ039
Benzimidazole
Stereochemistry
Proteinase inhibitor
Kinesins
Antimitotic Agents
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Combinatorial Chemistry Techniques
Humans
kinesin spindle protein inhibitor
010405 organic chemistry
Chemistry
Chemistry (all)
Biological activity
General Chemistry
General Medicine
0104 chemical sciences
Molecular Docking Simulation
Ugi reaction
Docking (molecular)
030220 oncology & carcinogenesis
antimitotic agent
Kinesin
Antimitotic Agent
Benzimidazoles
HeLa Cells
Subjects
Details
- ISSN :
- 21568944
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- ACS combinatorial science
- Accession number :
- edsair.doi.dedup.....7812aca90fb17c420ca55b38dbcd9d48