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Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
- Source :
- Biomedical Reports, CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2020
- Publisher :
- D.A. Spandidos, 2020.
-
Abstract
- Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process. Fil: Avila Rodríguez, María Isabela. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Meléndez Martínez, David. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Licona Cassani, Cuauhtemoc. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Aguilar Yañez, José Manuel. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México. Scicore Medical SAPI de CV; México Fil: Benavides, Jorge. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
- Subjects :
- 0301 basic medicine
Proteases
medicine.medical_treatment
maggot secretory products
fish epithelial mucus
Context (language use)
Review
Matrix metalloproteinase
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Wound care
0302 clinical medicine
matrix metalloproteases
medicine
purl.org/becyt/ford/3.4 [https]
General Pharmacology, Toxicology and Pharmaceutics
Protease
integumentary system
Maggot
business.industry
General Neuroscience
General Medicine
FISH-EPITHELIAL-MUCUS
Mucus
enzymatic wound treatment
PROTEASES
030104 developmental biology
030220 oncology & carcinogenesis
WOUND-HEALING
purl.org/becyt/ford/3 [https]
METALLOPROTEASES
business
Wound healing
snake venom proteases
Subjects
Details
- Language :
- English
- ISSN :
- 20499442 and 20499434
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biomedical Reports
- Accession number :
- edsair.doi.dedup.....780f5260cb8dc4702866f0553b2022f9