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Testing therapies less effective than the best current standard: ethical beliefs in an international sample of researchers
- Source :
- The American journal of bioethics : AJOB. 3(2)
- Publication Year :
- 2003
-
Abstract
- Objectives : To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard. Design : Using a web-based survey, we presented a hypothetical scenario proposing to test a therapy for HIV disease ("therapeutic inoculation") known to be less efficacious than highly active antiretroviral therapy (HAART). Respondents evaluated various trial designs as ethical or unethical. Participants : 604 subscribers to two listservs for individuals interested in international health research ethics. Main outcome measures : Proportion of respondents endorsing trials testing this "substandard" therapy, and proportion endorsing placebo-controlled trials. Results : There were 215 respondents from 47 countries. Forty-five percent of respondents were from low or middle income countries; 96% devoted at least some time to research activities; and 75% had "some" or "considerable" research expe...
- Subjects :
- medicine.medical_specialty
Consensus
Internationality
Anti-HIV Agents
Attitude of Health Personnel
education
Alternative medicine
Sample (statistics)
HIV Infections
Ethics, Research
Placebos
Medicine
Humans
Developing Countries
Randomized Controlled Trials as Topic
Resource poor
AIDS Vaccines
Research ethics
Clinical Trials as Topic
business.industry
Health Policy
Data Collection
Middle income countries
International health
Antiretroviral therapy
Control Groups
Research Personnel
Test (assessment)
Issues, ethics and legal aspects
Human Experimentation
Research Design
Family medicine
business
Clinical psychology
Subjects
Details
- ISSN :
- 15360075
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The American journal of bioethics : AJOB
- Accession number :
- edsair.doi.dedup.....780f083f24a2b507ec65b408401ef0b4