Drug-Polymer Conjugates with Tuberculostatic Activity, Based on Poly (N-Vinyl Pyrrolidone-alt-Itaconic Anhydride) and Novel Aminoacid Hydrazides

Authors :: Marcel Popa
Catalina Lionte
Delia Grebinisan
Valeriu Sunel
Cristian Peptu
Jacques Desbrieres
Mihaela Holban
'Gheorghe Asachi' Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection
Department of Natural Synthetic Polymers
Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM)
Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Source :: Polymer-Plastics Technology and Engineering, Polymer-Plastics Technology and Engineering, 2013, 52 (12), pp.1213-1219. ⟨10.1080/03602559.2013.798824⟩
Publication Year :: 2013
Publisher :: Informa UK Limited, 2013.
Abstract: cited By 4; International audience; Novel drug-polymer conjugates were prepared by chemical immobilization of hydrazides on poly (N-vinyl pyrrolidone-alt-itaconic anhydride) support. Hydrazides with tuberculostatic activity were synthesized as derivatives of N-(p-nitrobenzoyl)-L-glutamine. Elemental and spectral analysis confirmed the chemical structure of the newly synthesized compounds and the evaluation of biological activity showed an increase of the tuberculostatic effect and a lower toxicity by chemically linking the hydrazides onto co-polymer. © 2013 Copyright Taylor and Francis Group, LLC.

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