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Cytogenetic profile of adult AML patients in Turkey: a single center study with comprehensive comparison with literature
- Source :
- African Health Sciences; Vol. 22 No. 3 (2022); 183-191
- Publication Year :
- 2022
- Publisher :
- African Journals Online (AJOL), 2022.
-
Abstract
- Background: Cytogenetic findings are important prognostic factors in acute myeloid leukemia. Large systematic data about chromosomal characteristics of Turkish AML patients have not been reported to date. Objectives: The karyotypic profiles of 157 adult AML patients were evaluated retrospectively and compared with other reports from different populations. Methods: Cytogenetics analyses were performed on bone marrow samples using G-banding. Patients were categorized according to their cytogenetic results into four groups with the addition of a normal karyotyped group to the favorable, intermediate and adverse groups of European Leukemia Network. Results: Cytogenetic analyses were carried out successfully in 138 patients (88%). Abnormal karyotypes were found in 79 (57.2%) patients of which 13 (9.4%) were in favorable, 37 (26.8%) in intermediate and 29 (21%) in adverse groups. t(8;21) (5%) was the most common favorable abnormality while monosomal karyotypes (15.9%) in adverse group. Conclusion: This single center study is the most comprehensive study about the cytogenetic profile of acute myeloid leukemia in Turkey with comparison of other population-based studies. While there were similarities and differences with different publications, our results did not show a marked tendency to the findings of any specific geographic region. Keywords: Acute myeloid leukemia; cytogenetics; chromosomal abnormalities; adult.
- Subjects :
- Acute myeloid leukemia
cytogenetics
chromosomal abnormalities
adult
General Medicine
Subjects
Details
- ISSN :
- 17290503 and 16806905
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- African Health Sciences
- Accession number :
- edsair.doi.dedup.....77f5a61d327b8dd30770e05986d6d0fe