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Identification of drug repurposing candidates based on a miRNA-mediated drug and pathway network for cardiac hypertrophy and acute myocardial infarction
- Source :
- Human Genomics, Human Genomics, Vol 12, Iss 1, Pp 1-10 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central, 2018.
-
Abstract
- Background Cardiac hypertrophy and acute myocardial infarction (AMI) are two common heart diseases worldwide. However, research is needed into the exact pathogenesis and effective treatment strategies for these diseases. Recently, microRNAs (miRNAs) have been suggested to regulate the pathological pathways of heart disease, indicating a potential role in novel treatments. Results In our study, we constructed a miRNA-gene-drug network and analyzed its topological features. We also identified some significantly dysregulated miRNA-gene-drug triplets (MGDTs) in cardiac hypertrophy and AMI using a computational method. Then, we characterized the activity score profile features for MGDTs in cardiac hypertrophy and AMI. The functional analyses suggested that the genes in the network held special functions. We extracted an insulin-like growth factor 1 receptor-related subnetwork in cardiac hypertrophy and a vascular endothelial growth factor A-related subnetwork in AMI. Finally, we considered insulin-like growth factor 1 receptor and vascular endothelial growth factor A as two candidate drug targets by utilizing the cardiac hypertrophy and AMI pathways. Conclusion These results provide novel insights into the mechanisms and treatment of cardiac hypertrophy and AMI.
- Subjects :
- 0301 basic medicine
Vascular Endothelial Growth Factor A
Heart disease
lcsh:QH426-470
medicine.medical_treatment
Drug repurposing
Myocardial Infarction
lcsh:Medicine
Cardiomegaly
Acute myocardial infarction
030204 cardiovascular system & hematology
Bioinformatics
Receptor, IGF Type 1
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
microRNA
Genetics
Medicine
Animals
Humans
Gene Regulatory Networks
Myocardial infarction
cardiovascular diseases
Molecular Targeted Therapy
Molecular Biology
business.industry
Growth factor
lcsh:R
Drug Repositioning
Computational Biology
medicine.disease
Vascular endothelial growth factor
Drug repositioning
Vascular endothelial growth factor A
lcsh:Genetics
Cardiac hypertrophy
MicroRNAs
030104 developmental biology
chemistry
miRNAs
Molecular Medicine
business
Primary Research
Pathway
Subjects
Details
- Language :
- English
- ISSN :
- 14797364 and 14739542
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Human Genomics
- Accession number :
- edsair.doi.dedup.....77f38174b4e0a591c650164f7557c9a1