Back to Search
Start Over
Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors
- Source :
- Journal of perinatology : official journal of the California Perinatal Association. 38(10)
- Publication Year :
- 2018
-
Abstract
- The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduced in preterm infants by modifying certain systemic factors. There are steps that can be taken both early and late in the course of retinal vascular maturation that may potentially reduce an infant's risk of developing Type 1 ROP. In prethreshold stage 2-3 ROP without plus disease, a combination of supplemental oxygen, correction of severe anemia, and light adaptation to reduce rod photoreceptor oxygen consumption helped us to reduce ROP severity, and encouraged a return to a more physiologic retinal vascular maturation pattern. Thus, it may be possible to reduce the risk of developing Type 1 ROP by making adjustments in certain systemic parameters aimed at reducing retinal hypoxia, thereby gently lowering pathologically elevated levels of vascular endothelial growth factor (VEGF) within the eye.
- Subjects :
- Vascular Endothelial Growth Factor A
medicine.medical_specialty
Time Factors
genetic structures
Supplemental oxygen
VEGF receptors
Nutritional Status
Blindness
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Oxygen Consumption
030225 pediatrics
Ophthalmology
Medicine
Humans
Retinopathy of Prematurity
biology
business.industry
Adaptation, Ocular
Infant, Newborn
Oxygen Inhalation Therapy
Obstetrics and Gynecology
Infant
Retinopathy of prematurity
Retinal
Anemia
Hypoxia (medical)
medicine.disease
eye diseases
Vascular endothelial growth factor
Plus disease
Oxygen
Rod Photoreceptors
chemistry
Pediatrics, Perinatology and Child Health
030221 ophthalmology & optometry
biology.protein
sense organs
medicine.symptom
business
Subjects
Details
- ISSN :
- 14765543
- Volume :
- 38
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Accession number :
- edsair.doi.dedup.....77eca66765f61f170bb6c23e3c2eaf68