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Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease
- Source :
- Journal of Leukocyte Biology. 98:727-737
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- Inflammatory bowel disease is associated with a number of comorbidities that arise at extraintestinal sites, including the lung. Pulmonary manifestations reported in inflammatory bowel disease include bronchiectasis, chronic bronchitis and importantly, a range of subclinical respiratory abnormalities that are often overlooked in routine clinical evaluation. Whereas evidence for the pulmonary manifestations of Inflammatory bowel disease is increasing, little is known about the immunologic and physiologic mechanisms regulating cross-talk between the gut and lung during disease. This review examines reported lung involvement in Inflammatory bowel disease and discusses the possible immune pathways that underlie pulmonary pathologies. These mechanisms include dysfunctional immune-cell homing, systemic inflammation, and microbial dysbiosis; all of which may contribute to Inflammatory bowel disease-induced pulmonary inflammation. These mechanisms are discussed in the context of our current knowledge of the shared mucosal immune system and the immunology of Inflammatory bowel disease.
- Subjects :
- Inflammation
Chronic bronchitis
Lung
Bronchiectasis
Immunology
Pneumonia
Cell Biology
Disease
Biology
Inflammatory Bowel Diseases
medicine.disease
Systemic inflammation
Inflammatory bowel disease
medicine.anatomical_structure
medicine
Animals
Dysbiosis
Humans
Immunology and Allergy
Pulmonary pathology
medicine.symptom
Subjects
Details
- ISSN :
- 19383673 and 07415400
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Journal of Leukocyte Biology
- Accession number :
- edsair.doi.dedup.....77e4e969f66ede704c3173cf6620a29b