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One New Phenolic Compound from Castanea mollissima Shells and its Suppression of HepatomaCell Proliferation and Inflammation by Inhibiting NF-κB Pathway
- Source :
- International Journal of Molecular Sciences; Volume 20; Issue 3; Pages: 466, International Journal of Molecular Sciences, Vol 20, Iss 3, p 466 (2019)
- Publication Year :
- 2019
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2019.
-
Abstract
- Shells of Castanea mollissima (CMS), an agricultural remain and often considered waste from chestnut processing industry, have been proven a resource for traditional Chinese medicine. One new phenol, named castanolB(1), andsix known phenolic compounds (2⁻7) were isolated froma water-soluble extract of CMS. Their chemical structures were determined using preparative HPLC and various spectral analyses, and then were compared to literatures, which indicated the first identification of the seven compounds from C. mollissima. The physicochemical property of compound (2) was also reported for the first time. After antiproliferative screening of compounds (1⁻7) on LPS-induced SMMC-7721 and HepG2 hepatoma cells, castanolB (1) showed the best suppression. CastanolB(1) also significantly induced cell apoptosis. Furthermore, castanolB (1) decreasedsecretion of TNF-α and IL-6. Mechanistically, TLR4⁻NF-κB pathway was inhibited bycastanolB (1) with downregulation of TLR4, IKKβ, and NF-κB p65. This study presents a new phenol and shows its profiles of anticancer and anti-inflammation via inhibiting the TLR4⁻NF-κB pathway.
- Subjects :
- 0301 basic medicine
Inflammation
phenols
TLR4–NF-κB pathway
Catalysis
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
medicine
Phenol
Phenols
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Preparative hplc
Chemistry
Organic Chemistry
NF-κB
General Medicine
Computer Science Applications
Castanea mollissima shells
anti-inflammatory activities
anticancer activities
hepatoma cells
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Biochemistry
Apoptosis
030220 oncology & carcinogenesis
TLR4
medicine.symptom
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 20; Issue 3; Pages: 466
- Accession number :
- edsair.doi.dedup.....77e05976136adfc50ec76b34b302a117
- Full Text :
- https://doi.org/10.3390/ijms20030466