Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents

>> Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of doublestranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 29-deoxyoligocytidilates and telomerase inhibitors. Exp Biol Med 231:1283–1286, 2006