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Role of circulating microRNAs to predict hepatocellular carcinoma recurrence in patients treated with radiofrequency ablation or surgery
- Source :
- HPB. 24:244-254
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Background Loco-regional treatments have improved the survival of patients with early hepatocellular carcinoma (HCC), but tumor relapse is a frequent event and survival rates remain low. Moreover, conflicting evidences address early HCC patients to surgery or radiofrequency ablation (RFA), with the clinical need to find predictive non-invasive biomarkers able to guide treatment choice and define patients survival. Methods Two independent case series of treatment-naive HCC patients treated with local RFA, and a cohort of 30 HCC patients treated with liver surgery were enrolled. On the basis of literature evidence, we customized a panel of 21 miRNAs correlated with relapse and prognosis after local curative treatment of HCC. Results Expression levels of let-7c predict tumor relapse after RFA; we also investigated the same panel in a small cohort of HCC patients undergoing surgery, finding no statistically significance in predicting tumor relapse or survival. Moreover, interaction test indicated that let-7c expression levels are predictive for identifying a subset of patients that should be addressed to surgery. Conclusion Results from this study could predict prognosis of early HCC patients, helping to address early HCC patients to surgery or RFA treatment.
- Subjects :
- Liver surgery
medicine.medical_specialty
Carcinoma, Hepatocellular
Radiofrequency ablation
hepatocellular carcinoma, hepatectomy, radiofrequency, recurrence
law.invention
law
Humans
Neoplasm Recurrence, Local
Retrospective Studies
Treatment Outcome
Catheter Ablation
Circulating MicroRNA
Liver Neoplasms
MicroRNAs
Radiofrequency Ablation
medicine
Early Hepatocellular Carcinoma
In patient
Hepatology
business.industry
Carcinoma
Gastroenterology
Hepatocellular
medicine.disease
digestive system diseases
Surgery
Neoplasm Recurrence
Local
Early hcc
Hepatocellular carcinoma
Cohort
business
Subjects
Details
- ISSN :
- 1365182X
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- HPB
- Accession number :
- edsair.doi.dedup.....77c19a2dee2e9de65d977de718cccfd5