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Miliary Never-Smoking Adenocarcinoma of the Lung: Strong Association with Epidermal Growth Factor Receptor Exon 19 Deletion
- Source :
- Journal of Thoracic Oncology. 6:199-202
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a dramatic response to EGFR tyrosine kinase inhibitors. No echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) translocation was detected. We believe that the miliary never-soking adenocarcinoma of the lung is a distinct clinically relevant subgroup of the never-smoking non-small cell lung cancer. Physician should recognize this subgroup of patients with lung cancer when facing a picture of miliary pulmonary metastases in chest x-ray or computed tomography scan in patients with a history of never smoking and consider upfront therapy with EGFR tyrosine kinase inhibitors.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Lung Neoplasms
Oncogene Proteins, Fusion
Bone Neoplasms
Gene mutation
Polymerase Chain Reaction
Translocation, Genetic
Exon
Adenocarcinoma of the lung
Carcinoma
medicine
Humans
Epidermal growth factor receptor
Lung cancer
Aged
Neoplasm Staging
Sequence Deletion
biology
Brain Neoplasms
Carcinoma, Acinar Cell
Kinase
business.industry
Never smoker
Smoking
EGFR exon 19 deletion
Miliary lung metastases
DNA, Neoplasm
Exons
Middle Aged
Prognosis
medicine.disease
Lymphoma
ErbB Receptors
EGFR tyrosine kinase inhibitor
Oncology
Mutation
Cancer research
biology.protein
Female
business
Subjects
Details
- ISSN :
- 15560864
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology
- Accession number :
- edsair.doi.dedup.....77ba90e8fe273fb6971b885bd9edf1cf