Back to Search Start Over

The hallmarks of ovarian cancer: proliferation and cell growth

Authors :
José Antonio López-Guerrero
Raquel López-Reig
Source :
EJC Supplements, EJC Supplements, Vol 15, Iss, Pp 27-37 (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Epithelial ovarian cancer (EOC) is a heterogeneous group of diseases with distinct biological and clinical behaviour. Despite the differences between them, the capability of tumour cells to continuously proliferate and avoid death is maintained among histotypes. This ability is the result of alterations at different levels, causing the deregulation of cell cycle and proliferative-related pathways. Even if the leading role is played by RB and TP53, changes in other molecular pathways are involved in the development of EOC. This ability can be exploited to generate in vitro and in vivo models resembling the conditions of tumour development in a patient. In vivo models, such as patient-derived xenografts (PDX) or genetically engineered mouse models (GEMM), represent a fundamental tool in the study of the molecular mechanisms implicated in each EOC biotype for testing new therapeutic approaches. Herein we describe the major proliferation-related pathways and its disruption found in EOC and how these features can be used to establish in vivo models for translational research.<br />Highlights • Epithelial ovarian cancer (EOC) molecular biotypes are defined by distinct biology and clinical behaviour. • Sustained proliferation and resistance to cell death mechanisms characterised tumour cells. • RB and TP53 tumour-suppressor genes are highly implicated in EOC pathogenesis. • In vitro and in vivo models have a key role in the study of molecular mechanisms involved in EOC pathogenesis. • Development of animal models that mimic disease features constitute essential tools for new drugs testing.

Details

Language :
English
ISSN :
18781217 and 13596349
Volume :
15
Database :
OpenAIRE
Journal :
EJC Supplements
Accession number :
edsair.doi.dedup.....77aee77b4e9a32a78e11a68653b62206