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Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): A vehicle-controlled, double-blind study
- Source :
- Journal of Dermatological Treatment. 20:276-281
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- Topical tretinoin formulation is still unavailable in Japan. Because topical retinol, which is less potent but may cause less irritation, is available here, we have performed a randomized, blinded, vehicle-controlled study on the face using a once-nightly regimen for the treatment of mild photoaging in middle-aged Japanese females. First, a 26-week study was conducted in 57 subjects with a 0.075% retinol cream and its vehicle on each half side of the face. Three of the 57 subjects withdrew from the study due to irritation, although this rate was much smaller than that noted in our previous study with topical tretinoin. After 26 weeks, the rates of photoaging improvement were significantly higher on the retinol side: 27 out of 54 (50%) versus 13 (24%) for the fine wrinkling and 15 out of 54 (28%) versus 1 (2%) for deep wrinkling. A similar trial with a 0.04% retinol cream for 13 weeks revealed less prominent improvements in fine wrinkling but minimal irritation. From these data, we think that retinol creams, especially 0.04% cream, are suitable for daily use in the general population because of the low irritancy, even for those with sensitive skin.
- Subjects :
- Adult
medicine.medical_specialty
Administration, Topical
Photoaging
Population
Dermatology
medicine.disease_cause
Sensitive skin
law.invention
Cohort Studies
chemistry.chemical_compound
Double-Blind Method
Japan
Randomized controlled trial
law
Humans
Medicine
Vitamin A
education
education.field_of_study
business.industry
Retinol
Vitamins
Middle Aged
medicine.disease
Middle age
Skin Aging
Regimen
Treatment Outcome
chemistry
Face
Female
Pharmaceutical Vehicles
Irritation
business
Subjects
Details
- ISSN :
- 14711753 and 09546634
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Dermatological Treatment
- Accession number :
- edsair.doi.dedup.....77a5c4008dbc76592f6c5689c4cc5ec3