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Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease
- Source :
- The New England journal of medicine. 377(10)
- Publication Year :
- 2017
-
Abstract
- BackgroundPatients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in lung function in patients with mild or moderate COPD. MethodsIn a multicenter, randomized, double-blind, placebo-controlled trial that was conducted in China, we randomly assigned 841 patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate) severity to receive a once-daily inhaled dose (18 μg) of tiotropium (419 patients) or matching placebo (422) for 2 years. The primary end point was the between-group difference in the change from baseline to 24 months in the forced expiratory volume in 1 second (FEV1) before bronchodilator use. Secondary end points included the between-group difference in the change from baseline to 24 months in the FEV1 after bronchodilator use and the between-group difference in...
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Placebo
law.invention
03 medical and health sciences
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
law
Internal medicine
Bronchodilator
Forced Expiratory Volume
Administration, Inhalation
Clinical endpoint
Medicine
Humans
030212 general & internal medicine
Tiotropium Bromide
Aged
COPD
business.industry
General Medicine
Tiotropium bromide
Middle Aged
medicine.disease
Obstructive lung disease
respiratory tract diseases
Bronchodilator Agents
030228 respiratory system
Anesthesia
Disease Progression
Quality of Life
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15334406
- Volume :
- 377
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The New England journal of medicine
- Accession number :
- edsair.doi.dedup.....779e7f561ea3f44a7ecbf81e872aa283