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Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease

Authors :
Weimin Yao
Biao Liang
Yong-jian Xu
Lizhen Zeng
Xiongbin Li
Xiangyan Zhang
Yan Chen
Xiwei Hu
Lingshan Zeng
Pixin Ran
Bin Hu
Nanshan Zhong
Gang Chen
Qianli Ma
Jia Tian
Xiaodan Zhu
Rongchang Zhi
Jianping Zhao
Chunxue Bai
Weishu Ye
Ying Li
Yumin Zhou
Fenglei Li
Shengming Liu
Guoping Hu
Liping Wei
Juan Du
Shuqing Yu
Minjing Li
Zhe Shi
Ping Huang
Xiaochen Li
Jinping Zheng
Ronghuan Yu
Changzheng Wang
Xitao Ma
Changxiu Ye
Dongxing Zhao
Changli Yang
Canmao Xie
Wei-jie Guan
Yinhuan Li
Tao Chen
Xiufang Du
Shuyun Chen
Xiangwen Luo
Yingxiang Lin
Hui Tan
Xianwei Ye
Bingwen He
Jianping Gui
Source :
The New England journal of medicine. 377(10)
Publication Year :
2017

Abstract

BackgroundPatients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in lung function in patients with mild or moderate COPD. MethodsIn a multicenter, randomized, double-blind, placebo-controlled trial that was conducted in China, we randomly assigned 841 patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate) severity to receive a once-daily inhaled dose (18 μg) of tiotropium (419 patients) or matching placebo (422) for 2 years. The primary end point was the between-group difference in the change from baseline to 24 months in the forced expiratory volume in 1 second (FEV1) before bronchodilator use. Secondary end points included the between-group difference in the change from baseline to 24 months in the FEV1 after bronchodilator use and the between-group difference in...

Details

ISSN :
15334406
Volume :
377
Issue :
10
Database :
OpenAIRE
Journal :
The New England journal of medicine
Accession number :
edsair.doi.dedup.....779e7f561ea3f44a7ecbf81e872aa283