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Prognostic molecular markers in women aged 35 years or younger with breast cancer: is there a difference from the older patients?
- Source :
- Journal of clinical pathology. 64(9)
- Publication Year :
- 2011
-
Abstract
- Background Women aged ≤35 years with breast cancer have a poor prognosis, but their prognostic factors have not been clearly defined. Aims To evaluate whether the molecular markers used in age-unspecified breast cancer could also be applied to women ≤35 years. Methods Archival tumours from patients aged ≤35 years with stage I–III breast cancer were collected. Oestrogen receptor (ER), progesterone receptor (PR), HER2, Ki67 and P53 protein expression profiles in paraffin-embedded tissue sections were determined by immunohistochemistry. Tumours with an HER2 score of 2+ were further evaluated by fluorescence in situ hybridisation. Mutational analysis of exons 4–9 of the TP53 gene and exons 9 and 20 of the PIK3CA gene was carried out using direct sequencing analysis. Results 116 patients with a median follow-up duration of 62.7 months were included. In addition to tumour size and axillary lymph node status, univariate analysis showed that high Ki67 expression, ER-negative, HER2 overexpression, and TP53 mutations were associated with shorter overall survival. Multivariate analysis showed that high Ki67 expression (HR=3.93, p=0.005), HER2 overexpression (HR=3.21, p=0.013) and TP53 mutations (HR=4.44, p=0.005) were associated with shorter overall survival. PR expression and PIK3CA mutations were not associated with survival. Conclusions For women ≤35 years, TP53 mutations, Ki67 and HER2 expressions are strong prognostic factors. The limited prognostic value of hormone receptors suggests that the prognostic markers used in age-unspecified breast cancer may not be completely fit for this population.
- Subjects :
- Oncology
Adult
Genetic Markers
medicine.medical_specialty
Pathology
Class I Phosphatidylinositol 3-Kinases
Receptor, ErbB-2
Population
DNA Mutational Analysis
Taiwan
Breast Neoplasms
Biology
Disease-Free Survival
Pathology and Forensic Medicine
Phosphatidylinositol 3-Kinases
Breast cancer
Internal medicine
Progesterone receptor
medicine
Biomarkers, Tumor
Humans
Stage (cooking)
education
Lymph node
In Situ Hybridization, Fluorescence
Neoplasm Staging
education.field_of_study
Univariate analysis
Age Factors
General Medicine
DNA, Neoplasm
medicine.disease
Genes, p53
Prognosis
Survival Rate
medicine.anatomical_structure
Ki-67 Antigen
Hormone receptor
Immunohistochemistry
Female
Subjects
Details
- ISSN :
- 14724146
- Volume :
- 64
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of clinical pathology
- Accession number :
- edsair.doi.dedup.....77961098f4205ce8173421e175cf43b4