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crAssphage genomes identified in fecal samples of an adult and infants with evidence of positive genomic selective pressure within tail protein genes
- Source :
- Virus Res
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- crAssphages are a broad group of diverse bacteriophages in the order Caudovirales that have been found to be highly abundant in the human gastrointestinal tract. Despite their high prevalence, we have an incomplete understanding of how crAssphages shape and respond to ecological and evolutionary dynamics in the gut. Here, we report genomes of crAssphages from feces of one South African woman and three infants. Across the complete genome sequences of the South African crAssphages described here, we identify particularly elevated positive selection in RNA polymerase and phage tail protein encoding genes, contrasted against purifying selection, genome-wide. We further validate these findings against a crAssphage genome from previous studies. Together, our results suggest hotspots of selection within crAssphage RNA polymerase and phage tail protein encoding genes are potentially mediated by interactions between crAssphages and their bacterial partners.
- Subjects :
- Adult
Male
Cancer Research
Genome, Viral
Genome
Article
Bacteriophage
Feces
Young Adult
03 medical and health sciences
chemistry.chemical_compound
Negative selection
Caudovirales
Virology
RNA polymerase
medicine
Humans
Bacteriophages
Gene
Phylogeny
030304 developmental biology
Genetics
0303 health sciences
biology
030306 microbiology
Human gastrointestinal tract
Infant, Newborn
Infant
Genomics
Viral Tail Proteins
crAssphage
biology.organism_classification
Gastrointestinal Microbiome
Infectious Diseases
medicine.anatomical_structure
chemistry
Female
Subjects
Details
- ISSN :
- 01681702
- Volume :
- 292
- Database :
- OpenAIRE
- Journal :
- Virus Research
- Accession number :
- edsair.doi.dedup.....7792e1f847d0923be01a21e694f1c2f8