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Low prevalence of Chlamydia pneumoniae infections during the Mycoplasma pneumoniae epidemic season: Results of nationwide surveillance in Japan
- Source :
- Journal of Infection and Chemotherapy. 26:1116-1121
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective Chlamydia pneumoniae and Mycoplasma pneumoniae are both common causes of atypical pneumonia. We conducted an annual national survey of Japanese children to screen them for C. pneumoniae infections during the M. pneumoniae epidemic season. Methods Nasopharyngeal swab specimens were collected from children aged 0–15 years with suspected acute lower respiratory tract infection due to atypical pathogens, at 85 medical facilities in Japan from June 2008 to March 2018. Specimens were tested for infection using real-time polymerase chain reaction assays. Results Of 5002 specimens tested, 1822 (36.5%) were positive for M. pneumoniae alone, 42 (0.8%) were positive for C. pneumoniae alone, and 20 (0.4%) were positive for both organisms. In children with C. pneumoniae infection, the median C. pneumoniae DNA copy number was higher in those with single infections than in those with M. pneumoniae coinfection (p = 0.08); however it did not differ significantly according to whether the children had received antibiotics prior to sample collection (p = 0.34). Conclusions The prevalence of C. pneumoniae infection was substantially lower than that of M. pneumoniae infection during the study period. The change in prevalence of C. pneumoniae was not influenced by that of M. pneumoniae. Children with single C. pneumoniae infection are likely to have had C. pneumoniae infection, while those with coinfection are likely to have been C. pneumoniae carriers.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Mycoplasma pneumoniae
medicine.medical_specialty
medicine.drug_class
030106 microbiology
Antibiotics
medicine.disease_cause
law.invention
03 medical and health sciences
0302 clinical medicine
Japan
Community-acquired pneumonia
law
Internal medicine
Pneumonia, Mycoplasma
Prevalence
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Child
Epidemics
Chlamydophila Infections
Polymerase chain reaction
Chlamydia
business.industry
Chlamydia Infections
Chlamydophila pneumoniae
medicine.disease
respiratory tract diseases
Community-Acquired Infections
Infectious Diseases
Atypical pneumonia
Coinfection
Seasons
Sample collection
business
Subjects
Details
- ISSN :
- 1341321X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Infection and Chemotherapy
- Accession number :
- edsair.doi.dedup.....7787cfed936414327cefee191f3c1600