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Murine Model for Colitis-Associated Cancer of the Colon

Authors :
Amr M. Ghaleb
Ashley J. Snider
Vincent W. Yang
Yusuf A. Hannun
Agnieszka B. Bialkowska
Lina M. Obeid
Source :
Methods in Molecular Biology ISBN: 9781493936595
Publication Year :
2016

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

Details

ISBN :
978-1-4939-3659-5
ISSN :
19406029
ISBNs :
9781493936595
Volume :
1438
Database :
OpenAIRE
Journal :
Methods in molecular biology (Clifton, N.J.)
Accession number :
edsair.doi.dedup.....77676b60d924036143e85bcb01497742