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Murine Model for Colitis-Associated Cancer of the Colon
- Source :
- Methods in Molecular Biology ISBN: 9781493936595
- Publication Year :
- 2016
-
Abstract
- Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.
- Subjects :
- 0301 basic medicine
Male
Colorectal cancer
Azoxymethane
Inflammation
Inflammatory bowel disease
Article
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
medicine
Animals
Humans
Colitis
business.industry
Dextran Sulfate
Cancer
medicine.disease
Ulcerative colitis
digestive system diseases
Disease Models, Animal
030104 developmental biology
chemistry
Dysplasia
030220 oncology & carcinogenesis
Immunology
Colonic Neoplasms
Female
medicine.symptom
business
Subjects
Details
- ISBN :
- 978-1-4939-3659-5
- ISSN :
- 19406029
- ISBNs :
- 9781493936595
- Volume :
- 1438
- Database :
- OpenAIRE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Accession number :
- edsair.doi.dedup.....77676b60d924036143e85bcb01497742