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p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis
- Source :
- PLoS ONE, Vol 7, Iss 9, p e45820 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Background Previous studies on the association of p53 codon 72 (Arg72Pro) polymorphism with hematological malignancies risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of p53 Arg72Pro polymorphism on hematological malignancies risk. Methodology/Principal Findings Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: “p53”, “codon 72” “polymorphism” and “leukemia”, or “lymphoma”, or “myeloma”, thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. The overall results suggested that p53 Arg72Pro polymorphism was not associated with hematological malignancies risk. In stratified analyses, significantly increased non-Hodgkin lymphomas risk was found in p53 Arg72Pro polymorphism heterozygote model (Arg/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.02–1.35) and dominant model (Arg/Pro+Pro/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.03–1.34), but no significant association was found between leukemia risk and p53 Arg72Pro polymorphism. Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. Conclusions/Significance This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to non-Hodgkin lymphomas.
- Subjects :
- Oncology
Epidemiology
lcsh:Medicine
law.invention
Gene Frequency
law
hemic and lymphatic diseases
lcsh:Science
Epidemiological Methods
Polymerase chain reaction
Non-Hodgkin lymphoma
Chronic Lymphoblastic Leukemia
Multidisciplinary
Cancer Risk Factors
Lymphoma, Non-Hodgkin
Hematology
Acute Lymphoblastic Leukemia
Leukemia
Genetic Epidemiology
Meta-analysis
Medicine
Lymphomas
Research Article
Acute Myeloid Leukemia
Risk
medicine.medical_specialty
Genetic Causes of Cancer
Chronic Myeloid Leukemia
Biology
Polymorphism, Single Nucleotide
Predisposing Conditions and Syndromes
Genetic Mutation
Internal medicine
Leukemias
Genetics
medicine
Humans
Genetic Predisposition to Disease
Myelomas and Lymphoproliferative Diseases
Allele frequency
Genetic Association Studies
Evolutionary Biology
Population Biology
lcsh:R
Case-control study
Computational Biology
Human Genetics
Heterozygote advantage
Sequence Analysis, DNA
Publication bias
medicine.disease
Lymphoma
Amino Acid Substitution
Case-Control Studies
Hematologic cancers and related disorders
Immunology
lcsh:Q
Tumor Suppressor Protein p53
Publication Bias
Population Genetics
Hodgkin lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....7764ad2f24faf52122ee7098f7b309f2