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Expression of soluble vascular endothelial growth factor receptor-1 and placental growth factor in fetal growth restriction cases and intervention effect of tetramethylpyrazine
- Source :
- Asian Pacific Journal of Tropical Medicine. 7:663-667
- Publication Year :
- 2014
- Publisher :
- Medknow, 2014.
-
Abstract
- ObjectiveTo investigate the expression of soluble vascular endothelial growth factor receptor-1 (sFlt-1) and placental growth factor (PLGF) in the fetal growth restriction (FGR) cases and the intervention mechanism of tetramethylpyrazine.MethodsA total of 60 fetal growth restriction cases that admitted to our hospital were randomly divided into ligustrazine intervention group (group A) and nutritional support group (group B). A total of 50 healthy pregnant women were also enrolled as control group (group C). Expression level of maternal serum sFlt1, PLGF and fetal growth parameters including HC, AC, FL, BPD, EFW as well as placenta PLGF, sFlt-1 mRNA expression were recorded and compared among the three groups. A total of 15 SD rats were selected and were divided into three groups, TMP group, alcohol and tobacco group and blank control group. Three groups of rats were dissected on the twentieth day of gestation.ResultsExpression level of sFlt-1 and PLGF in group A was not significantly different from that of group C (P>0.05); but significant difference in SFlt1 and PLGF expression level was observed between group C and group B (P0.05). There was significant difference in PLGF between FGR group with treatment and FGR group without treatment or control group (P
- Subjects :
- Placental growth factor
medicine.medical_specialty
Placenta
Vasodilator Agents
Ligustrazine
sFlt-1
Intervention effect
Pregnancy Proteins
Fetal Development
Rats, Sprague-Dawley
chemistry.chemical_compound
PLGF
Pregnancy
Internal medicine
Fetal growth
Animals
Humans
Tetramethylpyrazine
Medicine
RNA, Messenger
Placenta Growth Factor
Medicine(all)
Fetal Growth Retardation
Vascular Endothelial Growth Factor Receptor-1
Traditional medicine
business.industry
Fetal growth restriction
General Medicine
Rats
Vascular endothelial growth factor
Endocrinology
chemistry
Pyrazines
embryonic structures
Female
business
Subjects
Details
- ISSN :
- 19957645
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Tropical Medicine
- Accession number :
- edsair.doi.dedup.....77627eaa90737bcd9777b654b7e3cd71