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MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination

MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination

Authors :
Piet Stinissen
Robert Medaer
David A. Hafler
Jef Raus
Jingwu Zhang
Source :
Science. 261:1451-1454
Publication Year :
1993
Publisher :
American Association for the Advancement of Science (AAAS), 1993.

Abstract

Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CD8+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.

Details

ISSN :
10959203 and 00368075
Volume :
261
Database :
OpenAIRE
Journal :
Science
Accession number :
edsair.doi.dedup.....775f86c610a980cc3eaca92fd51b9444
Full Text :
https://doi.org/10.1126/science.7690157