Back to Search
Start Over
MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
- Source :
- Science. 261:1451-1454
- Publication Year :
- 1993
- Publisher :
- American Association for the Advancement of Science (AAAS), 1993.
-
Abstract
- Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CD8+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.
- Subjects :
- Adult
Male
Multiple Sclerosis
Regulatory T cell
CD8 Antigens
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
T cell
T-cell vaccination
Biology
Lymphocyte Activation
Immunotherapy, Adoptive
Cell Line
Epitopes
Interleukin 21
medicine
Humans
Cytotoxic T cell
IL-2 receptor
Antigen-presenting cell
Multidisciplinary
Vaccination
Myelin Basic Protein
Middle Aged
Natural killer T cell
medicine.anatomical_structure
CD4 Antigens
Immunology
Female
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 261
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....775f86c610a980cc3eaca92fd51b9444
- Full Text :
- https://doi.org/10.1126/science.7690157