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Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
- Source :
- Journal of pharmaceutical sciences. 77(5)
- Publication Year :
- 1988
-
Abstract
- The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were approximately 50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.
- Subjects :
- Male
Nicotine
Disposition kinetics
Pharmaceutical Science
Pharmacology
Beagle
chemistry.chemical_compound
Dogs
Species Specificity
medicine
Toxicokinetics
Animals
Cotinine
Lagomorpha
biology
Stereoisomerism
Metabolism
biology.organism_classification
Pyrrolidinones
chemistry
Female
Rabbits
Enantiomer
medicine.drug
Half-Life
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 77
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....775416251b43c62d1a7561718786b915