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Prognostic role of preoperative albumin to globulin ratio in predicting survival of clear cell renal cell carcinoma
- Source :
- International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology, International Brazilian Journal of Urology, Vol 44, Iss 5, Pp 933-946, International braz j urol, Volume: 44, Issue: 5, Pages: 933-946, Published: OCT 2018, International braz j urol v.44 n.5 2018, International Braz J Urol, Sociedade Brasileira de Urologia (SBU), instacron:SBU
- Publication Year :
- 2018
- Publisher :
- Sociedade Brasileira de Urologia, 2018.
-
Abstract
- yavuz y koparal, murat/0000-0002-8347-5727 WOS: 000446097700012 PubMed: 29757575 Purpose: To investigate the prognostic role of preoperative albumin/globulin ratio (AGR) in predicting disease-free survival (DFS) and overall survival (OS) in localized and locally advanced clear cell renal cell carcinoma (RCC) patients. Patients and Methods: 162 patients who met the criteria specified were included in the study. the DFS and OS ratios were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the prognostic factors affecting DFS and OS. Results: Median follow-up period was 27.5 (6-89) months. There was a statistically significant relationship between low AGR and high pathological tumor (pT) stage, presence of collecting system invasion, presence of tumor necrosis, and a high platelet count (p = 0.012, p = 0.01, p = 0.001, and p = 0.004, respectively). According to the Kaplan-Meier survival analysis, both OS and DFS were found to be significantly lower in the low AGR group (p = 0.006 and p = 0.012). in the multivariate Cox regression analysis, collecting system invasion and tumor necrosis were found to be independent prognostic factors in predicting OS and pT stage was found to be an independent prognostic factor in predicting DFS (HR: 4.08, p = 0.043; HR: 8.64, p = 0.003 and HR: 7.78, p = 0.041, respectively). Conclusion: in our study, low AGR was found to be associated with increased mortality and disease recurrence in localized and locally advanced RCC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Globulin
Adolescent
Urology
030232 urology & nephrology
lcsh:RC870-923
urologic and male genital diseases
Gastroenterology
Sensitivity and Specificity
Disease-Free Survival
03 medical and health sciences
Young Adult
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Albumins
medicine
Carcinoma
Biomarkers, Tumor
Humans
Stage (cooking)
Child
Pathological
Carcinoma, Renal Cell
Survival analysis
Serum Albumin
Aged
Retrospective Studies
Aged, 80 and over
biology
Proportional hazards model
business.industry
Albumin
Renal Cell
Globulins
Middle Aged
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Prognosis
Kidney Neoplasms
Clear cell renal cell carcinoma
030220 oncology & carcinogenesis
biology.protein
Original Article
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 16776119 and 16775538
- Volume :
- 44
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology
- Accession number :
- edsair.doi.dedup.....7746d3e0f1255532544cc3eae8033279