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Gender specific differences in left ventricular remodelling in obesity may explain differences in obesity related mortality
- Source :
- Journal of Cardiovascular Magnetic Resonance, Vol 14, Iss Suppl 1, p P75 (2012), Journal of Cardiovascular Magnetic Resonance
- Publication Year :
- 2012
-
Abstract
- Summary Across both genders, obesity, in the absence of traditional cardiovascular risk factors, is characterized by concentric LV remodeling. Whereas males show predominantly concentric remodeling, females exhibit eccentric and concentric hypertrophy. This may explain the observed gender difference in obesity related cardiovascular mortality. Background Obesity related cardiovascular mortality, although elevated when compared to normal weight, is lower in females (♀ )t han males ( ♂ )a t every body mass index (BMI) level. Given the fact that males have less fat tissue than females at each BMI level, the reasons behind this trend are unlikely to be attributable to the effects of excess adiposity alone. As different patterns of left ventricular (LV) remodeling have been shown to have varying prognostic value, with concentric hypertrophy being more strongly predictive of cardiovascular mortality than eccentric hypertrophy, our aim was to investigate whether sex-specific differences in LV remodeling could provide an additional explanation for the observed gender difference in obesity related mortality. Methods 703 subjects (♀ n= 390, ♂ n=313) without identifiable cardiovascular risk factors, (BMI range 15.7-59.2 Kg/ M2) underwent cardiovascular magnetic resonance at 1.5 Tesla for the assessment of LV mass (g), enddiastolic volume (EDV; ml) and LV mass/volume ratio (LVM/VR).
- Subjects :
- Medicine(all)
2. Zero hunger
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Pathology
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Concentric hypertrophy
Adipose tissue
Magnetic resonance imaging
Eccentric hypertrophy
medicine.disease
Obesity
lcsh:RC666-701
Internal medicine
Poster Presentation
Cardiology
Medicine
Eccentric
Radiology, Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine
business
Body mass index
Angiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532429X
- Volume :
- 14
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- J Cardiovasc Magn Reson
- Accession number :
- edsair.doi.dedup.....774301be1d59b409c98d9afe6f7a5282