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The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable
- Source :
- Neurobiology of Aging. 41:115-121
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Late-onset Alzheimer’s disease (LOAD) can present heterogeneously, with several subtypes recognized, including dysexecutive AD. One way to identify people with dysexecutive AD is to consider the difference between memory and executive functioning, which we refer to as the executive prominent/memory prominent spectrum. We aimed to determine if this spectrum was heritable. We used neuropsychological and genetic data from people with mild LOAD (Clinical Dementia Rating 0.5 or 1.0) from the National Alzheimer’s Coordinating Center and the Alzheimer’s Disease Neuroimaging Initiative. We cocalibrated the neuropsychological data to obtain executive functioning and memory scores and used their difference as a continuous phenotype to calculate its heritability overall and by chromosome. Narrow-sense heritability of the difference between memory and executive functioning scores was 0.68 (standard error 0.12). Single nucleotide polymorphisms on chromosomes 1, 2, 4, 11, 12, and 18 explained the largest fraction of phenotypic variance, with signals from each chromosome accounting for 5%–7%. The chromosomal pattern of heritability differed substantially from that of LOAD itself.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Clinical Dementia Rating
Single-nucleotide polymorphism
Disease
Polymorphism, Single Nucleotide
Chromosomes
Article
Executive Function
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Alzheimer Disease
Memory
Databases, Genetic
medicine
Humans
Genetic Predisposition to Disease
Psychiatry
Aged
Aged, 80 and over
General Neuroscience
Neuropsychology
Genetic data
Heritability
medicine.disease
Phenotype
030104 developmental biology
Female
Neurology (clinical)
Geriatrics and Gerontology
Alzheimer's disease
Psychology
030217 neurology & neurosurgery
Developmental Biology
Clinical psychology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....7742cecfbc0fba012bca74df5b19679f