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Effects of intramuscular olanzapine vs. haloperidol and placebo on QTc intervals in acutely agitated patients
- Source :
- Psychiatry Research. 119:113-123
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Prolongation of the QTc interval has been reported during treatment with oral antipsychotic agents and may be more pronounced during parenteral administration. Pooled QTc interval data from acutely agitated patients across four double-blind trials were compared. Databases included: placebo-controlled [two schizophrenia, one bipolar mania trials (n=565)]; haloperidol-controlled [two schizophrenia trials (n=482)]; geriatric placebo-controlled [1 dementia trial (n=204)]. Patients received 1-3 injections of intramuscular (IM) olanzapine (2.5-10 mg/injection), IM haloperidol (7.5 mg/injection), or IM placebo. At 2 and 24 h after IM olanzapine treatment, the mean QTc interval decreased approximately 3 ms from baseline in the placebo- and haloperidol-controlled databases. When there was a statistically significant difference between IM olanzapine and IM placebo, QTc intervals decreased during treatment with IM olanzapine and increased with IM placebo. The incidences of prolonged (endpoint >/=99th percentile of healthy adults or >/=500 ms) or lengthened (increase >/=60 ms) QTc intervals during treatment with IM olanzapine (
- Subjects :
- Olanzapine
Bipolar Disorder
Psychomotor agitation
medicine.medical_treatment
Placebo
Injections, Intramuscular
QT interval
Benzodiazepines
Electrocardiography
Double-Blind Method
mental disorders
Haloperidol
medicine
Humans
Antipsychotic
Psychomotor Agitation
Biological Psychiatry
Dose-Response Relationship, Drug
Dopamine antagonist
Long QT Syndrome
Psychiatry and Mental health
Anesthesia
Schizophrenia
Dementia
medicine.symptom
Psychology
Mania
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research
- Accession number :
- edsair.doi.dedup.....773e72cdff26911ebf4385f76944bd7d