Back to Search
Start Over
QbD steered fabrication of Pullulan-Terminalia catappa-Carbopol®971P film forming gel for improved rheological, textural and biopharmaceutical aspects
- Source :
- International Journal of Biological Macromolecules. 193:1301-1312
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The developed FFG possess pseudoplastic, viscoelastic, thixotropic characteristics leading to good spreadability (35.71 ± 1.72 g·s, work of shear; 452.73 ± 8.23 g, firmness). Upon solvent evaporation, FFG converted in situ into bioadhesive film (81.90 ± 3.24 g) leading to longer residence on skin surface, prolonged delivery and ~1.3 fold enhanced CTZ skin retention as compare to commercial cream as evident from biopharmaceutical analysis, which is ideal for skin infections treatment. The simulation analysis suggested ≥10 μg/mL (MIC against C. albicans) CTZ concentration maintained for 2 times the days in rat skin as well as human skin as compared to commercial cream. Overall, the developed FFG system ascertained to be promising delivery system for treatment of chronic skin conditions.
- Subjects :
- Male
Thixotropy
Bioadhesive
Human skin
Biochemistry
chemistry.chemical_compound
Rheology
Structural Biology
medicine
Animals
Humans
Glucans
Molecular Biology
Skin
chemistry.chemical_classification
Biological Products
Shear thinning
Chromatography
Viscosity
Clotrimazole
Pullulan
General Medicine
Polymer
Rats
chemistry
Terminalia
Female
Gels
medicine.drug
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....773b0f211404b73ac5a888c162ee014a