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Specific recognition of loop DNA by dicationic porphyrins
- Source :
- Chemistrybiodiversity. 4(7)
- Publication Year :
- 2007
-
Abstract
- A series of dicationic porphyrins were found to specifically recognize loop structures of oligodeoxynucleotides, and to selectively oxidize guanine residues upon photo-irradiation at micromolar concentrations. These compounds could, thus, be employed as promising structural probes for specific secondary DNA structures. The production of singlet oxygen ((1)O2) is responsible for the DNA-modification profiles. Both UV-titration and thermal-melting experiments indicate that the strong affinity of the charged porphyrins towards DNA loops is responsible for these molecular-recognition phenomena.
- Subjects :
- Binding Sites
Porphyrins
Chemistry
Guanine
Singlet oxygen
Stereochemistry
Bioengineering
General Chemistry
General Medicine
DNA
Biochemistry
Loop (topology)
chemistry.chemical_compound
Molecular recognition
Molecular Medicine
Nucleic Acid Conformation
Spectrophotometry, Ultraviolet
Molecular Biology
Subjects
Details
- ISSN :
- 16121880
- Volume :
- 4
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Chemistrybiodiversity
- Accession number :
- edsair.doi.dedup.....773953fc8d97d9586751608e30276e86