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Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- The CCAAT sequence is a ubiquitous cis-element of eukaryotic promoters, and genes containing CCAAT sequences have been shown to be activated by the CCAAT-binding transcription factor complex in several eukaryotic model organisms. In general, CCAAT-binding transcription factors form heterodimers or heterotrimeric complexes that bind to CCAAT sequences within the promoters of target genes and regulate various cellular processes. To date, except Hap complex, CCAAT-binding complex has been rarely reported in fungi. In this study, we characterized two CCAAT-binding transcription factors (Fct1 and Fct2) in the plant pathogenic fungus Fusarium graminearum. Previously, FCT1 and FCT2 were shown to be related to DNA damage response among eight CCAAT-binding transcription factors in F. graminearum. We demonstrate that the nuclear CCAAT-binding complex of F. graminearum has important functions in various fungal developmental processes, not just DNA damage response but virulence and mycotoxin production. Moreover, the results of biochemical and genetic analyses revealed that Fct1 and Fct2 may form a complex and play distinct roles among the eight CCAAT-binding transcription factors encoded by F. graminearum. To the best of our knowledge, the results of this study represent a substantial advancement in our understanding of the molecular mechanisms underlying the functions of CCAAT-binding factors in eukaryotes.
- Subjects :
- 0106 biological sciences
0301 basic medicine
DNA damage
Science
Transcription factor complex
Biology
01 natural sciences
Article
Fungal Proteins
03 medical and health sciences
Fungal genetics
Fusarium
Heterotrimeric G protein
Gene Expression Regulation, Fungal
Gene
Transcription factor
Regulation of gene expression
Genetics
Cell Nucleus
Multidisciplinary
Virulence
food and beverages
Promoter
Pathogenic fungus
Mycotoxins
030104 developmental biology
CCAAT-Binding Factor
Fungal pathogenesis
Medicine
010606 plant biology & botany
DNA Damage
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....772d24ebcf4129b6fbd3449c7cd77d86