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Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease
- Source :
- Blood Coagulation & Fibrinolysis. 22:487-492
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- Nitric oxide production is reduced in renal disease, partially due to decreased endothelial nitric oxide production. Evidence indicates that nitric oxide deficiency contributes to cardiovascular events and progression of kidney damage. A polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene is a candidate gene in cardiovascular and renal diseases. We investigated a potential involvement of this polymorphism in chronic renal failure. A case-control study involved 78 children with chronic kidney disease (CKD) and 30 healthy controls. All participants were genotyped for the ecNOS4 polymorphism by the polymerase chain reaction (PCR). Dialyzed (maintenance hemodialysis) and conservative treatment children had significantly higher frequency of the aa genotype and ecNOS4a allele (P
- Subjects :
- medicine.medical_specialty
Candidate gene
Adolescent
Genotype
Nitric Oxide Synthase Type III
Disease
Nitric Oxide
Severity of Illness Index
Nitric oxide
chemistry.chemical_compound
Gene Frequency
Renal Dialysis
Risk Factors
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Renal Insufficiency, Chronic
Allele
Child
Alleles
Kidney
Polymorphism, Genetic
business.industry
Hematology
General Medicine
medicine.disease
Introns
medicine.anatomical_structure
Endocrinology
chemistry
Case-Control Studies
Hypertension
Egypt
Gene polymorphism
business
Kidney disease
Subjects
Details
- ISSN :
- 09575235
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Blood Coagulation & Fibrinolysis
- Accession number :
- edsair.doi.dedup.....77289b25b0660ac6ff42c8a21b0da6f4