Back to Search
Start Over
Hyperkalemia and renin-angiotensin aldosterone system inhibitor therapy in chronic kidney disease: A general practice-based, observational study
- Source :
- PLoS ONE, Vol 14, Iss 3, p e0213192 (2019), PLoS ONE
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- © 2019 Jun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data on hyperkalemia frequency among chronic kidney disease (CKD) patients receiving renin-angiotensin aldosterone system inhibitors (RAASis) and its impact on subsequent RAASi treatment are limited. This population-based cohort study sought to assess the incidence of clinically significant hyperkalemia among adult CKD patients who were prescribed a RAASi and the proportion of patients with RAASi medication change after experiencing incident hyperkalemia. We conducted a retrospective, population-based cohort study (1 January 2013–30 June 2017) using Australian national general practice data from the NPS MedicineWise’s MedicineInsight program. The study included adults aged 18 years who received 1 RAASi prescription during the study period and had CKD (estimated glomerular filtration rate [eGFR] 6 mmol/L or a record of hyperkalemia diagnosis) and among patients who experienced incident hyperkalemia, the proportion who had RAASi medication changes (cessation or dose reduction during the 210-day period after the incident hyperkalemia event). Among 20,184 CKD patients with a median follow-up of 3.9 years, 1,992 (9.9%) patients experienced an episode of hyperkalemia. The overall incidence rate was 3.1 (95% CI: 2.9–3.2) per 100 person-years. Rates progressively increased with worsening eGFR (e.g. 3.5-fold increase in patients with eGFR
- Subjects :
- Male
Hyperkalemia
Physiology
General Practice
030232 urology & nephrology
Angiotensin-Converting Enzyme Inhibitors
Cardiovascular Medicine
030204 cardiovascular system & hematology
urologic and male genital diseases
Biochemistry
Geographical Locations
Renin-Angiotensin System
Endocrinology
0302 clinical medicine
Chronic Kidney Disease
Medicine and Health Sciences
Lipid Hormones
Aldosterone
Aged, 80 and over
education.field_of_study
Multidisciplinary
Incidence (epidemiology)
Middle Aged
female genital diseases and pregnancy complications
Nephrology
Cardiovascular Diseases
Medicine
Female
Anatomy
medicine.symptom
Research Article
Glomerular Filtration Rate
Cohort study
Adult
medicine.medical_specialty
Adolescent
General Science & Technology
Endocrine Disorders
Science
Oceania
Population
Cardiology
Renal function
Angiotensin Receptor Antagonists
Young Adult
03 medical and health sciences
Internal medicine
Diabetes Mellitus
medicine
Humans
Renal Insufficiency, Chronic
education
Aged
Proportional Hazards Models
Retrospective Studies
Heart Failure
Renal Physiology
business.industry
Australia
Biology and Life Sciences
nutritional and metabolic diseases
Kidneys
Retrospective cohort study
Renal System
medicine.disease
Hormones
Discontinuation
Logistic Models
Metabolic Disorders
People and Places
Potassium
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....771ae2062dfd423dc0c7bf0af28f0558