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Forward chemical genetics: library scaffold design
- Source :
- ResearcherID
- Publication Year :
- 2004
-
Abstract
- With the unraveling of the entire human genome, it has become imperative to understand the function of the gene products, proteins. Within the past several years, chemical genetics has gained recognition as a powerful approach to study protein function by using small molecules as gene knock-out or knock-in mimics. Forward chemical genetics is a three-step process; the design and synthesis of a small molecule library represents the first step followed secondly by the search for novel phenotypes and then by isolation and identification of target protein(s). This review will focus on the first step, the design of the scaffold for small molecule libraries. It will also examine the connection between the choice of a scaffold and the propensity of that library to demonstrate enhanced biological activity when tested in certain cellular systems.
- Subjects :
- Proteomics
Scaffold
Triazines
Organic Chemistry
Small Molecule Libraries
Quantitative Structure-Activity Relationship
General Medicine
Computational biology
Biology
Combinatorial chemistry
Small molecule
Computer Science Applications
Styrenes
Purines
Sphingosine
Drug Design
Drug Discovery
Animals
Humans
Human genome
Target protein
Chemical genetics
Function (biology)
Subjects
Details
- ISSN :
- 13862073
- Volume :
- 7
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Combinatorial chemistryhigh throughput screening
- Accession number :
- edsair.doi.dedup.....76f4abc02c9f3475f1dc509116b8d23f