Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring

Offspring of parents with exceptional longevity manifest lower prevalence of cardiovascular disease (CVD) but the role of lifestyle factors in this unique cohort is not known. Our study tested whether individuals with exceptional parental longevity have lesser prevalence of CVD independent of lifestyle factors. Prevalence of CVD and CVD risk factors was assessed in a population of community dwelling Ashkenazi Jewish adults aged 65-94 years. Participants included offspring of parents with exceptional longevity (OPEL, n=395), defined as having at least one parent living past the age of 95 years, and offspring of parents with usual survival (OPUS, n=450), defined as having neither parent survive to 95 years. Medical and lifestyle information was obtained using standardized questionnaires. Socioeconomic status was defined based on validated classification scores. Dietary intake was evaluated with the Block Brief Food Frequency Questionnaire (FFQ 2000) in a sub-group of the study population (n=234). Our study found no significant differences in the prevalence of obesity, smoking, alcohol use, physical activity, social strata scores and dietary intake between the two groups. After adjustment for age and sex, the OPEL demonstrated 29% lower odds of having hypertension (95% CI 0.53-0.95), 65% lower odds of having had a stroke (95% CI 0.14-0.88), and 35% lower odds of having CVD (95% CI 0.43-0.98), compared with OPUS. In conclusion, exceptional parental longevity is associated with lower prevalence of CVD independent of lifestyle, socioeconomic status and nutrition; thus, highlighting the potential role of genetics in disease-free survival among individuals with exceptional parental longevity.