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A five‐mRNA signature associated with post‐translational modifications can better predict recurrence and survival in cervical cancer
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- High mortality of patients with cervical cancer (CC) stresses the imperative of prognostic biomarkers for CC patients. Additionally, the vital status of post‐translational modifications (PTMs) in the progression of cancers has been reported by numerous researches. Therefore, the purpose of this research was to dig a prognostic signature correlated with PTMs for CC. We built a five‐mRNA (GALNTL6, ARSE, DPAGT1, GANAB and FURIN) prognostic signature associated with PTMs to predict both disease‐free survival (DFS) (hazard ratio [HR] = 3.967, 95% CI = 1.985‐7.927; P
- Subjects :
- CD4-Positive T-Lymphocytes
0301 basic medicine
Oncology
medicine.medical_specialty
cervical cancer
Human Protein Atlas
tumour‐infiltrating immune cells
Uterine Cervical Neoplasms
Kaplan-Meier Estimate
Lymphocyte Activation
03 medical and health sciences
0302 clinical medicine
Internal medicine
Databases, Genetic
Humans
Medicine
Effective treatment
post‐translational modifications
RNA, Messenger
Cervical cancer
Messenger RNA
business.industry
Gene Expression Profiling
CD4+ Memory T Cell
High mortality
Hazard ratio
biomarkers
Reproducibility of Results
Molecular Sequence Annotation
Original Articles
Cell Biology
Middle Aged
Prognosis
medicine.disease
Progression-Free Survival
Gene Expression Regulation, Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Posttranslational modification
Molecular Medicine
Original Article
Female
activated CD4 memory T cell
Neoplasm Recurrence, Local
business
Immunologic Memory
Protein Processing, Post-Translational
Subjects
Details
- ISSN :
- 15824934 and 15821838
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine
- Accession number :
- edsair.doi.dedup.....76e3befb2d8ba90cf6fc746b21a723e6
- Full Text :
- https://doi.org/10.1111/jcmm.15270