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Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane
- Source :
- Journal of Periodontal & Implant Science
- Publication Year :
- 2019
- Publisher :
- Korean Academy of Periodontology, 2019.
-
Abstract
- Purpose To overcome several drawbacks of chemically-crosslinked collagen membranes, modification processes such as ultraviolet (UV) crosslinking and the addition of biphasic calcium phosphate (BCP) to collagen membranes have been introduced. This study evaluated the efficacy and biocompatibility of BCP-supplemented UV-crosslinked collagen membrane for guided bone regeneration (GBR) in a rabbit calvarial model. Methods Four circular bone defects (diameter, 8 mm) were created in the calvarium of 10 rabbits. Each defect was randomly allocated to one of the following groups: 1) the sham control group (spontaneous healing); 2) the M group (defect coverage with a BCP-supplemented UV-crosslinked collagen membrane and no graft material); 3) the BG (defects filled with BCP particles without membrane coverage); and 4) the BG+M group (defects filled with BCP particles and covered with a BCP-supplemented UV-crosslinked collagen membrane in a conventional GBR procedure). At 2 and 8 weeks, rabbits were sacrificed, and experimental defects were investigated histologically and by micro-computed tomography (micro-CT). Results In both micro-CT and histometric analyses, the BG and BG+M groups at both 2 and 8 weeks showed significantly higher new bone formation than the control group. On micro-CT, the new bone volume of the BG+M group (48.39±5.47 mm3) was larger than that of the BG group (38.71±2.24 mm3, P=0.032) at 8 weeks. Histologically, greater new bone area was observed in the BG+M group than in the BG or M groups. BCP-supplemented UV-crosslinked collagen membrane did not cause an abnormal cellular reaction and was stable until 8 weeks. Conclusions Enhanced new bone formation in GBR can be achieved by simultaneously using bone graft material and a BCP-supplemented UV-crosslinked collagen membrane, which showed high biocompatibility and resistance to degradation, making it a biocompatible alternative to chemically-crosslinked collagen membranes.<br />Graphical Abstract
- Subjects :
- Biocompatibility
0206 medical engineering
02 engineering and technology
Absorbable implants
Periodontal Science
03 medical and health sciences
0302 clinical medicine
Animals
Bone regeneration
Chemistry
Collagen membrane
030206 dentistry
Bone area
Biphasic calcium phosphate
Biocompatible material
020601 biomedical engineering
Hydroxyapatite-beta tricalcium phosphate
Membrane
Ultraviolet rays
Periodontics
Collagen
Oral Surgery
Bone volume
Biomedical engineering
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20932286 and 20932278
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Periodontal & Implant Science
- Accession number :
- edsair.doi.dedup.....76d80c0a8c5283674e486128a32a70b3