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Risk Factors Associated with Aggravation of Cervical Spine Lesions in Patients with Rheumatoid Arthritis
- Source :
- Spine. 47:484-489
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- STUDY DESIGN A retrospective cohort study. OBJECTIVE To examine factors related to severe aggravation of pre-existing cervical lesions in patients with rheumatoid arthritis (RA) under current pharmacologic treatments with biologics. SUMMARY OF BACKGROUND DATA Advanced RA cervical lesions carry a risk of irreversible damage to the spinal cord; however, risk factors for aggravation are unclear after the use of biologics became more popular. METHODS Of 166 patients with pre-existing cervical lesions at baseline, 87 who had cervical X-ray images taken at baseline and at the final visit (with an interval of more than 1 year) were evaluated retrospectively. Aggravated instabilities determined at the final visit were defined as follows: atlantoaxial subluxation (AAS) = atlantodental interval ≧ 10 mm; vertebral subluxation (VS) = a Ranawat value < 10 mm; and sub-axial subluxation (SAS) = an anterior vertebral slip ≧ 4 mm or a multi-level slip ≧ 2 mm. Patients were divided into two groups based on the radiographic results: severe aggravation and non-severe aggravation. Explanatory variables were gender, age of RA onset, duration of disease, average observation period, Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) at baseline, drug treatment history, presence of mutilating deformities in the hands, presence of RA-related joint surgery, and the prevalence of each cervical lesion at baseline. RESULTS The severe group comprised 14 patients (16.1%). There was no significant difference between the two groups with respect to demographic data. Multivariate logistic regression analysis revealed that pre-existing SAS lesions (odds ratio: 7.59, 95% confidence interval: 1.16-49.6) and no history of biologic treatment (odds ratio, 0.10; 95% confidence interval, 0.17-0.58) were associated with aggravation. CONCLUSIONS Pre-existing SAS lesions were associated with aggravation. Meanwhile, biologics may be effective at preventing aggravation.Level of Evidence: 3.
- Subjects :
- Joint Instability
medicine.medical_specialty
Joint Dislocations
Disease
Logistic regression
Arthritis, Rheumatoid
Risk Factors
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Longitudinal Studies
Retrospective Studies
Subluxation
business.industry
Retrospective cohort study
Odds ratio
medicine.disease
Confidence interval
medicine.anatomical_structure
Atlanto-Axial Joint
Rheumatoid arthritis
Cervical Vertebrae
Disease Progression
Neurology (clinical)
business
Vertebral subluxation
Subjects
Details
- ISSN :
- 15281159 and 03622436
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Spine
- Accession number :
- edsair.doi.dedup.....76d518132fe5fe43a610fd6f4b180740