Back to Search
Start Over
Effects of Coronary Blood Flow on Left Ventricular Function in Essential Hypertensive Patients
- Source :
- Hypertension Research. 23:239-245
- Publication Year :
- 2000
- Publisher :
- Japanese Society of Hypertension, 2000.
-
Abstract
- To elucidate the mechanism of left ventricular dysfunction associated with left ventricular hypertrophy in hypertension, coronary blood flow (CBF) and left ventricular mass (LVM) were measured in 62 patients with essential hypertension (mean age, 54±13 years) and 22 normotensive control subjects (mean age, 57 ±13 years). According to the indicator fractionation principle, CBF/cardiac output (CO), estimated on the basis of the ratio of myocardial uptake/total injected dose of thallium-201 (% cardiac uptake), was measured. CBF and CBF per 100g of myocardium (unit CBF) were calculated according to the following formulas: CBF=% cardiac uptake×CO, and unit CBF=(CBF/LVM)×100, where CO and LVM are echocardiographically determined. Midwall fractional shortening (FS) and isovolumic relaxation time (IRT) were calculated as the indices of systolic and diastolic functions. CBF was greater in hypertensives than in controls (218.2±74.0 vs. 187.4±40.4ml/min, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Cardiac output
Systole
Physiology
Diastole
Left ventricular hypertrophy
Essential hypertension
Ventricular Function, Left
Predictive Value of Tests
Coronary Circulation
Internal medicine
Internal Medicine
medicine
Humans
Radionuclide Imaging
Aged
Ventricular function
business.industry
Blood flow
Middle Aged
medicine.disease
Control subjects
Thallium Radioisotopes
Echocardiography
Hypertension
cardiovascular system
Cardiology
Regression Analysis
Female
Hypertrophy, Left Ventricular
Cardiology and Cardiovascular Medicine
Isovolumic relaxation time
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 13484214 and 09169636
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Hypertension Research
- Accession number :
- edsair.doi.dedup.....76cabafec9d96da8522e8bf94c716750